BUS LAW wk3 dq Assignment Example | Topics and Well Written Essays - 250 words

BUS LAW wk3 dq - Assignment Example Rudy becomes irate and tells Marie she will be hearing from his attorney. Is there an enforceable contract in this situation? Identify and discuss the elements of a valid contract and predict whether Rudy can legally compel Marie to surrender the paint sprayer.   No, there was no enforceable contract since Marie and Rudy did not have a written agreement which transferred the paint sprayer to Rudy. An enforceable contract would require two important aspects that are associated with statue of frauds and concept of acceptance. Hence, in this case if one party only agreed to the contract without signing it, Rudy cannot legally compel Marie to give her paint sprayer. aâ‚ ¬? Felipe Underwood is a famous artist whose portraits are in demand nationwide. Doris Williams thinks it will give her prestige to own an Underwood portrait, so she pays Felipe $50,000 to paint her portrait from a photograph. Unknown to Doris, Felipe gives the photograph to Malina because he has accepted another com mission to paint the portrait of the president, and Malina completes the portrait. When Doris has a party to unveil her portrait, an art critic guest tells her that although the portrait is painted in the Underwood style, it is a fake. Dorisaâ‚ ¬Ã¢â€ž ¢s attorney files suit against Felipe for breach of contract and for seeking specific performance.

Chance & Story Essay Example for Free

Chance Story Essay In third grade through sixth, I had a friend named Chance. We were best friends and often spent long days and nights over at each other’s house. Whenever I stayed at Chance’s, the house was filled with noise from the two of us and his six brothers and sisters. Chance’s family was Mormon, a religion that my family knew nothing about except the name. He once explained why his family was so large, but it made little sense to me at that time. During the summer between sixth and seventh grade Chance’s family moved away to Utah. I’ve learned a bit more about Mormons since but this assignment offered me an opportunity to learn more about the religion of my friend and how Mormons feel about how they are perceived in the United States, especially concerning the law and discrimination. Chance’s family was only one of many Mormons in my town and surrounding areas. Patty is a good friend of mine who attends the Mormon church in town since she was a baby, so through her I was able to find three people to interview. Her parents were not available, but she introduced me to a Mormon missionary Brian, a neighbor Barbara, and Chris, her mother’s home- teacher. Brian is twenty years old and is originally from Nova Scotia, Canada. He is currently nearing the end of his Mormon mission, which is a semi-required two year work for Mormon young men to an area chosen by the head church in Salt Lake City, Utah. He had just graduated high school when he began the training for the mission. His mission is to go door to door in the neighborhoods to share his beliefs and teach anyone interested about the basics of the church. Barbara is also not originally from this area. She was born and raised in Provo, Utah, which is where the Mormon university Brigham Young is located. She moved here ten years ago when her husband’s job transferred. She is forty-three years old, has five children between six and fifteen, has a college degree from BYU in marketing but doesn’t currently work outside her home, and has been married for twenty-three years. Chris is from this area and has lived here all of his fifty-six years. He is an elder at the church, has four children and sixteen grandchildren so far, works as a machine repairer, and volunteers for the church as a home-teacher in which he regularly visits church members for further teaching about the church. Having such different subjects to interview proved very interesting. Each shared that they have dealt with some sort of discrimination in their lifetimes as Mormons. They all indicated that the problems are rarely very serious and never violent, but are more subtle. Barbara notices the negative attitude towards Mormons most of the three because she lived for so long in Utah, which is heavily populated with Mormons, especially where she lived in Provo. She said that when the family moved, she was surprised to find that there are people who still believe Mormons are the many-wives religion. One woman at her children’s school even asked once if Barbara was one of several wives of her husband. Neither Brian nor Chris said that they have had this problem. Brian said his problem is more centered on his mission work. He has often heard people say ‘there go the two-by-twos. ’ The missionaries work in pairs, so he said the term stuck. For the most part, he says people are friendly towards him and often comment that Mormons are the nicest people they know, but very few choose to actually discuss the church’s teachings. Instead Brian and Chris both said that most people are interested in if Mormons are a cult that traps unsuspecting victims. Barbara also said this is something people have asked in round-about ways such as through her kids. All three said that it is often frustrating the poor view that they feel the majority of Americans have toward the Mormon Church. Barbara and Chris’s children mostly have other Mormon friends, and those that are not Mormon are seldom allowed to attend activities organized for the Mormon youth such as dances, outings, or sport activities if they are to be held at the church. They say that no one has said directly why the kids can’t attend, but all three believe that it is related to the negative view of the church. They all also indicated that any issues that arise are always social in nature, that they have never had a problem with employers or the law regarding discrimination. Interestingly, as I interviewed each person, I found myself also curious about the ‘oddities’ of the Mormon church. When Barbara mentioned the many-wives idea, I wanted to know more about it. So I was doing exactly what the three had said most people do: expressing curiosity about the strangeness instead of the good qualities of the church or its teachings. However, I did learn quite a bit about the basic structure of the church, why it is based in Utah, and how Mormons view the world and the after-life. Since the problems that Mormons experience are almost always social, it is a matter of slowly changing the public’s view of the church. Chris believes that the commercials the church has put on television have gone a long way in changing perceptions about the church. Brian said that attitudes are better in Canada towards the church most likely because it started in the USA, where it experienced a lot of discrimination in its beginnings. So it is a matter of time and continued sharing for the Mormon Church to be recognized as a legitimate religion and not as a cult.

Distinguishing Fear From Anxiety

Distinguishing Fear From Anxiety Introduction Anxiety disorders constitute the largest group of mental diseases in European countries {Andlin-Sobocki et al., 2005, Eur J Neurol, 12 Suppl 1, 1-27}. Human anxiety disorders can be categorized into generalized anxiety disorders, panic attacks, Posttraumatic stress disorders (PTSD), Obsessive-compulsive disorder (OCD) and special phobias, are amongst the most prevalent with a 28% lifetime prevalence and an incidence of 18% {Kessler et al., 2005, Arch Gen Psychiatry, 62, 617-27}. Pathological expression of both fear and anxiety are thought to represent certain aspects of anxiety disorders. Specific phobias are considered, as fear disorders, whereas generalized anxiety is viewed as an example of anxiety disorders.   PTSD patients do not only suffer from conditioned fear symptoms to discrete cues that act as a reminder of a previous trauma, but they also exhibit persistent symptoms of sustained anxiety. The regulation of fear and anxiety is the heart of many psychopathological di sorders also reflected in the extremely high comorbidity rate with other mood disorders, such as depression. Up to 90% of individuals expressing an anxiety disorder also develop depression, which could increase suicide rates (Gorman, 1997) and constitutes a significant problem for the community in general. Currently available pharmacotherapies such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have emerged as effective alternatives to the benzodiazepines and have been paralleled by a similar growth in effective and available psychological treatments, particularly cognitive and cognitive-behavioural therapy. A considerable portion of patients, however, requires long-term treatment throughout the whole life or does not respond at all. For coping with these limitations, focusing on a better understanding of these diseases and improved treatment is urgently needed. Distinguishing fear from anxiety Fear Vs Anxiety Fear- Behavioural manifestation associated with clearly identified imminent threat. Anxiety- Generalized fear without object, an apprehensive anticipation of future potential threats The main function of fear and anxiety is to act as a signal of danger, threat, or motivational conflict, and to trigger appropriate adaptive responses. For some authors, fear and anxiety are indistinguishable, whereas others believe that they are distinct phenomena. In particular fear is a generalized adaptive state of apprehension to an imminent threat (Michael Davis, 2010). It begins rapidly and dissipates rapidly once a threat is removed. Fear is provoked by imminent and real danger, Animals may learn to fear situations in which they have previously been exposed to pain or stress, and subsequently show avoidance behavior when they re-encounter that situation. Young animals may show an innate fear reaction to sudden noise or disturbances in the environment, but rapidly become habituated to them. When they are used to a familiar environment, then a fear of novelty may develop. Ethologists have also made the important observation that fear is often mixed up with other aspects of moti vation. Thus, conflict between fear and approach behavior may results in displacement activities (e.g., self-grooming in rats and mice). Such displacement activities may be the behavioral expression of an anxious state. In contrast anxiety is often elicited by less specific and less predicable threats (Michael Davis, 2010). Anxiety is a generalized response to an unknown threat or internal conflict, whereas fear is focused on known external danger. It has been suggested, anxiety can only be understood by taking into account some of its cognitive aspects, particularly because a basic aspect of anxiety appears to be uncertain. Originally, anxiety is associated with arousal and vigilance, as a result it can be defined as longer lasting state of apprehension that can become pathological if its become extreme.    Defense and coping strategies Fear or anxiety, result in the expression of a range of adaptive or defensive behaviors, which are aimed to escape from the source of danger or motivational conflict. These behaviors depend on the context and the repertoire of the species. Fight or flight, was coined exactly 75 years ago, in 1929, Walter Cannon originally formulated this term for the human response to threat, Fear and anxiety. The phrase fight or flight has influenced the understanding and expectations of both clinicians and patients. However, both the order and the completeness of Cannons famous phrase are suspect. Fight or flight mischaracterizes the ordered sequence of responses that mammals exhibit as a threat escalates or approaches. In recent years, ethologists working with nonhuman primates have clearly established distinct fear responses that proceed sequentially in response to increasing threat. The order of these responses may have important implications for understanding and treating acute stress in humans . The sequence, originally described by Jeffrey A. Gray, begins with what ethologists call the freeze response or freezing, terms corresponding to what clinicians typically refer to as hypervigilance (being on guard, watchful, or hyper-alert). This initial freeze response is the stop, look, and listen response associated with fear. The survival advantage of this response is obvious. Specifically, ethological research has demonstrated that prey that remains frozen during a threat are more likely to avoid detection because the visual cortex and the retina of mammalian carnivores primarily detect moving objects rather than color. Immobilization or freezing, are usually elicited when the threat is inescapable, and is characterized by autonomic inhibition (hypotension, bradycardia), and a more pronounced increase in the neuroendocrine response activation of the hypothalamopituitary-adrenal axis and increased glucocorticoid secretion. This type of passive response was originally described by Engel Schmale as a conservation-withdrawal strategy. The concept of alternative (active/passive) strategies itself owes much to the work of Henry and coworkers. Specific brain circuits appear to mediate distinct coping reactions to different types of stressors. Psychopathological fear/anxiety Although fear acts as a physiological signal of danger, threat, or motivational conflict, it can become pathological and interfere with the ability to survive. Development of specific anxiety disorders, i.e., social phobia, obsessive-compulsive and panic disorders or specific phobias are consequences of pathological fear expression. Anxiety disorders are marked by excessive future fear, often in response to specific objects or situations and in the absence of a true danger. Anxiety disorders are extremely common in the general population. According to a recent epidemiological study, the lifetime prevalence of any anxiety disorder is 28.8% (Kessler et al, 2005). Increased anxiety in animal models, as a trait, can be attributed to at least two sets of factors: (i) a genetic predisposition, essentially linked to the expression of genes that are involved in the various neurochemical mechanisms underlying fear and anxiety; and (ii) the influence of environmental factors. These environmental factors can interact with the expression of the relevant genes during early development and determine the functional properties of the neural and biochemical systems involved in coping with stressful events. They can also modulate the learning processes that occur at a later stage, when the individual is confronted with various life events, and determine the capacity to cope successfully with aversive or threatening situations in adulthood. These predisposing factors, either innate or acquired, determine individual affective styles or coping strategies, which are thought to play an important role in vulnerability to psychopathology. Brain structures and functional circuitry involved in fear/anxiety Limbic System: Emotional brain Limbic areas include the hippocampus (HPC), amygdala, cortex, thalamus, hypothalamus and the bed nucleus of striaterminalis (BNST). Hippocampus and amygdala are considered as a main area involves in emotion, but I will mainly focus on the amygdala. Hippocampus The hippocampus is a part of the forebrain, located in the medial temporal lobe. The hippocampus consists of the dentate gyrus, the Cornu Ammonis fields (CA1-CA3), and the subiculum. The main information input to the hippocampus is via the entorhinal cortex and the main information output from the hippocampus is via the subiculum. Between entorhinal cortex and subiculum, three major pathways of the hippocampus are described. The perforant pathway from entorhinal cortex forms excitatory connections with the granule cells of the dentate gyrus (Bliss and Lomo, 1973). The mossy fiber pathway, formed by the axons of the granule cells of the dentate gyrus, connects the granule cells with the pyramidal cells in the area CA3 of the hippocampus (Lu et al., 1997). The Schaffer collateral pathway connects the pyramidal cells of the CA3 region with the pyramidal cells in the CA1 region of the hippocampus (Collingridge et al., 1983). Amygdala The amygdala is a limbic system structure and is a key target area implicated in emotional processing. It is composed of several interconnected nuclei located in the medial temporal lobes in mammals and is reciprocally linked to sensory cortices, thalamus, and autonomic control centers (Sah et al., 2003). Its internal and external connections permit the amygdala to evaluate environmental stimuli, attach salience to them, then generate appropriate autonomic, endocrine, and behavioral responses (Adolphs, 1999; Rogan LeDoux, 1996; Walker Davis, 2002). In addition, the amygdala is involved in detecting and evaluating emotional expression (Adolphs, 1999). The lateral nucleus of the amygdala (LA) has been implicated as the critical area where sensory stimuli achieve emotional salience. Consequently, the amygdala is needed for proper emotional processing, as in fear and anxiety, memory, and attention (Davis, 1997; Keele, Hughes, Blakeley, Herman, 2008; LeDoux, Cicchetti, Xagoraris, Roma nski, 1990). Plasticity in neurotransmission is important in maintaining the emotional significance of stimuli we encounter (Ehrlich, 2009). However, if those synapses and circuits become super-sensitized, what was once adaptive emotional behaviors can become psychopathologies, such as anxiety disorders and depression (Keele, 2005; Rosen Shulkin, 1998). Amygdala structure The amygdaloid complex is comprised of 13 nuclei, which are further divided into 3 groups: the basolateral complex, the cortical nuclei, and the centromedial nuclei. The basolateral complex is composed primarily of the basolateral (BLA) and lateral (LA) amygdala nuclei (Keele et al., 2008; Sah et al., 2003). Neuroanatomical studies reveal that there are extensive internuclear and reciprocal intranuclear connections (Pitkanen, Savander, LeDoux, 1997). Physiological studies further suggest that the amygdala nuclei are primarily individual functional units with the flow of information through the amygdala being highly organized, as seen in fear conditioning studies (LeDoux, 2000). Sensory afferents (context + tone) terminate in the LA (Romanski, Clugent, Bordi, LeDoux, 1993). The information proceeds in a predominantly unidirectional flow from the lateral to medial at which point the LA sends glutamatergic projections to the central nucleus of the amygdala (CeA), as well the BLA and o ther nuclei (Sah et al., 2003; Pitkanen et al., 1997; Smith Par eacute;, 1994). The CeA, where much of the amygdala nuclei projections converge and insubstantial intra-amygdaloid fibers exit, constitutes the output of the amygdala (Sah et al., 2003; Pitkanen et al., 1997). Two main cell types have been described morphologically and physiologically in the BLA (Rainnie, Asprodini, Shinnick-Gallagher, 1993; Sah et al., 2003). The first type is glutamatergic projection neurons that give off collaterals within the nucleus. They account for 70% of the neuronal population (McDonald, 1982). Their secondary and tertiary dendrites appear spiny, distinguishing them from the other neuronal type (Sah et al., 2003). In the LA, pyramidal neurons account for about 95% of the population. Pyramidal neurons show broad action potentials and spike frequency accommodation of varying degrees, and express N-methyl-D-aspartic acid (NMDA), a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and k ainate receptors. Main input to these neurons is cortical and thalamic, but they are highly modulated by interneurons and monoaminergic afferents from brain stem nuclei (Marowsky, Yanagawa, Obata, Vogt., 2005; Rainnie, 1999; Sah et al., 2003; Sullivan, Coplan, Kent, Gorman, 1999). The second type of neurons is interneurons, also called stellate cells (Sah et al., 2003). They account for 5-10% of the neurons in the BLA and are local circuit gamma-aminobutyric acid (GABA) releasing cells with short duration action potentials and no spike frequency accommodation. AMPA receptors are expressed but NMDA receptors are reportedly absent (Sah et al., 2003). Like the projection neurons, input is cortical and thalamic with modulatory input from brainstem nuclei (Lang and Par eacute;, 1998). Afferent and Efferent Connectivity Amygdala innervation consists of sensory input from the thalamus and cerebral cortex and autonomic input from the hypothalamus and brain stem (Keele et al., 2008; Sah et al., 2003). All sensory modalities glutamatergically project to the amygdala via the thalamus, sensory cortices, association cortices, and other polymodal cortical areas (McDonald, 1998; Romanski LeDoux, 1993; Sah et al., 2003). Brain stem projections provide monoaminergic modulation of the amygdala. There is extensive serotonergic innervation from the dorsal raphe nucleus (DRN), dopaminergic innervation from the ventral tegmental area, and noradrenergic innervation from the locus coeruleus (Clayton Williams, 2000;Marowsky et al., 2005; McIntyre, Power, Roozendaal, McGaugh, 2003; Rainnie, 1999). Main output of the amygdala is projected from the CeA. Lesion and stimulation studies have shown cortical, hypothalamic, and brain stem regions to be target areas, directly and indirectly through projections to the bed nuc leus of the stria terminalis (Iwata, Chida, LeDoux, 1987; LeDoux, Iwata, Cicchetti, Reis, 1988; LeDoux, 2000; Sah et al., 2003; Turner, Mishkin, Knapp, 1980; Walker Davis, 2002). CeA efferents modulate specific behavioral and autonomic responses to fear, anxiety, and stress (Davis, 1997; Rosen Schulken, 1998; Sah et al., 2003). The CeAs connection to the hypothalamus allows activation of the sympathetic nervous system, such as an increase in heartbeat, galvanic skin response, and pupil dilation in response to fear. For inducing behavioral responses to fear, there are projections from the CeA to brainstem nuclei. For instance, connections with the periaqueductal gray induce freezing behavior and with the nucleus reticularis pontis caudalis (PnC) increase acoustic startle response (Davis, 1992). The brainstem innervation is so extensive that the amygdala contacts almost every brainstem region involved in autonomic functioning (Keele et al., 2008; LeDoux, 1992; Price, 2003). Behavioral Function The amygdalas contribution to emotion has long been documented. Initially, monkey bilateral temporal lobectomy studies performed by Klà ¼ver and Bucy (1937 1939), resulted in agnosia, hyperorality, hypersexuality, social withdrawl, difficulty recognizing emotionality of objects, and placidity. This became known as Klà ¼ver-Bucy syndrome. In following amygdalectomy studies a loss of fear, aggression, and normal social interactions with an increase in exploration was found (Goddard, 1964; Aggleton Young, 2000). Rodent lesion studies further demonstrated decreased active fear avoidance (Poremba Gabriel, 1999) and decreased passive conditioned fear response (Roozendaal, Koolhaas, Bohus, 1993), for instance, amygdala lesioned rats fail to show freezing behavior in the presence of danger, such as a cat (Blanchard Blanchard, 972). Specific lesioning of the lateral nucleus of the amygdala blocked conditioned fear (LeDoux et al., 1990). Amygdalectomized humans also show impairments in fear conditioning (LaBar, LeDoux, Spencer, Phelps, 1995). Additionally, human subjects do not recognize fear from facial expressions, voices, (Adolphs, Tranel, Damasio, Damasio, 1995), or music (Gosselin et al., 2005), and judge deceitful looking individuals as trustworthy (Adolphs, Tranel, Damasio, 1998). Stimulation and activation studies further corroborate amygdala lesion evidence. Human amygdala stimulation often produces observable fear responses as well as subjective feelings of fear (for review see Davis, 1992). Functional magnetic resonance imaging (fMRI) further shows activation of the amygdala during viewing of fearful faces (Rosen Donley, 2006) and following fear conditioning when the conditioned stimulus is presented (LaBar, Gatenby, Gore, LeDoux, Phelps, 1998). In animals, amygdala stimulation shows an increase in behaviors, such as, vigilance, attention, and arousal (Rosen Schulkin, 1998) and an increase in autonomic responding; such as, respiration, heart rate, and blood pressure (for review see Davis, 1992). Additional emotions reported in humans have been anger and rage (Joseph, 2000). One female subject displayed enraged facial expressions, lips retracted and grimacing, then progressed to aggressive behavior and attack (Mark, Ervin, Sweet, 1972). These are emotional behavior autonomic responses that are often a component of the fear response. Fear Conditioning and Long-Term Potentiation One commonly used technique for studying amygdala function in both animals and humans is conditioned fear learning (Bà ¼chel, Morris, Dolan, Friston, 1998; Walker Davis 2002). To accomplish this type of learning a neutral sensory stimulus (conditioned stimulus or CS, often a light or tone) is paired with a noxious stimulus (unconditioned stimulus or US) such as a mild electric shock. Upon repeated US-CS pairing the learned association between the two stimuli elicits a behavioral response (conditioned response or CR) that can last indefinitely with o nly a few pairings (Maren, 2005). The convergence of the cortical sensory input and thalamic relays from the spinothalamic tract in the amygdala as well as the abolishment of learned fear response after amygdala lesions implicate it as the site for conditioned fear learning (LeDoux et al., 1990; Ledoux, 2000). The learned association as well as the fear behavioral response is seen across many species and has been extensively studied in rats, cats, primates, and humans. The neural mechanisms have also been conserved across these animal species and probably humans as well (LeDoux, 1996; Price, 2003). Long-term potentiation (LTP) functions as a mechanism for increasing synaptic strength between two neurons. Experimentally it can be induced by tetanic stimulation of afferent fibers; however, naturally occurring similar mechanisms are induced in the LA during conditioned fear learning (McKernan Shinnick-Gallagher, 1997; Rogan LeDoux, 1996; LeDoux, 2000). Support comes from the observat ion that before conditioning, neurons in the LA respond to CS and US input. After conditioning, the postsynaptic neurons response to the CS is greatly enhanced. This suggests that fear conditioning provides a suitable means for examining amygdala synaptic plasticity and fear circuitry. The proposed LTP molecular mechanism initiating fear conditioning is that the CS induces a release of glutamate, which activates the glutamatergic receptors on postsynaptic LA neurons. The US further depolarizes the neurons causing the release of the Mg2+ block in the NMDA receptors (NMDARs) allowing an influx of Ca2+. The additional Ca2+ initiates second messenger cascades that are responsible for the increased neuronal response to the CS. Blocking NMDARs with the antagonist DL-2-amino-5- phosphonovalerate (APV) prevents the acquisition of fear conditioning. If APV is delivered after training it does not affect the consolidation of the fear memory further supporting the necessary involvement of NMDAR s in the LTP mechanism. Ca2+ influx due to L-type voltage-gated calcium channels (L-VGCCs) is also required for the association to occur. The L-VGCCs may be opening in response to the strong depolarization from the US, especially when postsynaptic spiking and back-propagating action potentials occur. How learned fear memories are acquired and the mechanisms involved is essential to understanding normal amygdala functioning. Fear conditioning provides a means for studying dysfunction of fear circuitry and the resulting abnormal fear behaviors. Fear circuitry receives intense inhibitory modulation. When the inhibition is removed the fear conditioning mechanisms, such as LTP, are unmodulated and the circuitry enters a hyperexcited state. This could potentially lead to abnormally enhanced fear associations resulting in heightened fear responses. Manipulating the fear circuitry by altering inhibitory modulators and then assessing the fear behavior responses could elucidate the mechanisms leading to fear and anxiety disorders. Neuropeptide Y (NPY) system: Involvement in fear and anxiety NPY: Overview Neuropeptide Y(NPY) was isolated from porcine brain more than two decades ago (Tatemoto et al., 1982). This 36-amino-acid residue is one of the most abundant peptides found in the central nervous system (CNS) of all mammals, including humans {Chan-Palay et al., 1985; Chan-Palay et al., 1986}. It is one of the most conserved peptides in evolution (Larhammar, 1996; Larhamar and Salaneck, 2004), suggesting an important role in the regulation of basic physiological functions (Larhammar et al., 1993). At present, five NPY receptor subtypes have been cloned and designated-Y1, Y2, Y4, Y5, and y6 (Dumont et al., 1993; Gehlert, 1994; Michel et al., 1998)-all of which couple to Gi/o proteins and inhibit the production of cyclic AMP (Palmiter et al., 1998). NPY has important modulatory functions in the immune and cardiovascular systems (Song et al., 1996; Michalkiewicz et al., 2001), circadian rhythms (Antonijevic et al., 2000; Yannielli and Harrington, 2001), food intake (Jolicoeur et al., 199 5), and seizure (Husum et al., 1998; Colmers and El Bahh, 2003) and the response to pain (Munglani et al., 1996). NPY is involved in anxiety related behaviors (Thorsell and Heilig, 2002), and there is increasing support for the role of NPY in mood disorders such as depression (Redrobe et al., 2002a). It is constantly reported that NPY producing anxiolytic-like effect and can be observed different battery of behavioral tests like elevated plus maze, light dark, open field, and stressed induced hyperthermia. Consistent findings across different rodent modes have been proving the true anxiolytic effect of NPY. The presence of different NPY receptors and the plethora of NPY-induced behavioral effect raise the question as to whether NPY and its receptors have an effect on fear, and extinction of conditioned fear. The NPY Y1 receptors can be found in number of brain regions but prominent in cerebral cortex, amygdala, and hippocampus (Kask et al., 2002). The majority of studies have been proved the involvement of NPY Y1 receptor in the regulation of anxiety. In the present study I am focusing on fear reducing properties of NPY following the hypothesis that anxiolytic-like effect of NPY mediated my Y1 receptors.

Loneliness in William Faulkners A Rose For Emily and Anton Chekhovs Misery :: A Rose for Emily, William Faulkner

Loneliness in William Faulkner's A Rose For Emily and Anton Chekhov's Misery Although the authors, setting, and time period of each story is unique, the character of Miss Emily in "A Rose For Emily" by William Faulkner and Iona in "Misery" by Anton Chekhov share much in common.   Iona and Emily spent their entire lives searching for fulfillment. At the end of their lives they are still lonely souls - never achieving fulfillment. It is so terrible with "A Rose For Emily," the horrible feelings come up immediately when the story ends with two dead bodies in the old and dirty house. One is Homer Barron, Emily's lover. The other is Emily herself. What a pity for a woman like Emily. No, Emily is not really a woman. She is just a child (or a daughter). Since being born, her life was framed strictly by her selfish father." Miss Emily, a slender figure in white in the background, her father a large silhouette in the foreground, his back to her and clutching a horsewhip, the two of them framed by the back-flung front door." Miss Emily could not find her own real life. And then her father died. Everyone in town was very pleased that Emily might have a chance to be happy from then on. But very shortly after the shock of her father's death, Emily had another shock when her sweetheart left her alone and went away. Nobody was expecting that. Poor Emily! She was just a little girl having no experience over thirty years of age. Homer, the young man that everyone believed would marry her, was just a liar, as well. And as a result, Emily killed Homer and lay beside his dead body for years. At the age of forty, Emily was still a child -- an old child with loneliness and unfulfilled soul. William Faulkner introduces the story with the gathering of the whole town at Emily's death. The author marks a big curious question for all readers. What happened and how? Then he goes back to the past of Miss Emily, leading us to travel around the closed time circle of her life: present back to past and past to present. This is an unusual order. The normal time order consists the progression of the human being from birth through youth, to age and final death. The confusion that Faulkner has given produces a confusion in Emily's life.

To Ill :: essays research papers

"Shoot all the blue jays you want, if you can hit ‘em, but remember it’s a sin to kill a mockingbird." Lee says that it is a sin to kill a mockingbird because they only make music for people to enjoy, and they do no damage to anything such as other birds do. Lee is right the mockingbird dose nothing wrong, such as the mockingbirds in the book. They never do anything wrong, but they sometimes are misunderstood and considered bad by other people. Boo is one of the mockingbirds in the book. He only gives to the children. He gives them many different things through the knothole in the tree. Boo also gives the children a game to play during the day, "Boo Radley." Later Boo gives them the most important thing of all, their lives. He is also a mockingbird in another way, when Scout falls out of the tire he gives them his music, laughter. At the end of the book Boo ends up going back into his house never to be seen again by Scout. He did this because he was a mockingbird caged up for a long time and was not ready to be free. The solution for him was to go back to his cage that he knew and was safe. The other mockingbird is Tom Robinson because he does not do anything wrong. He was a very nice man, he would do things for people if they needed something done that they could not do themselves. An example of this is when he helps Mayella and refused to accept the money that she offered him. The difference between him and Boo is that even though he did not do anything wrong he was still found guilty of a crime that he probably did not commit. The reason that Tom was convicted is mainly because he was a back man accused of a crime by a white woman. The common thing that both of these characters share is that they are both somehow connected to Bob Ewell. Boo is connected to him because Boo killed him when he attacked the children. Tom is connected to Bob because Bob is the main reason that Tom was tried and found guilty in the first place. This common connection to Bob connects Boo and Tom because the reason that Bob attacked the children was because he wanted to get back at the rest of the world for what it did to him.

Essay --

n the play "Tragedy of Macbeth", William Shakespeare presents many examples of foreshadowing which pulls the reader in and displays an interesting and unique way of story telling. Right from the beginning in (Act 1, Scene 1) three witches appear who are the main sources of foreshadowing and start the entire story by agreeing with one another to meet up again "when the battle's lost and won". Further along in the play the actual prophecies given by the three witches occur when they meet Macbeth and Banquo then greet Macbeth with three titles "Thane of Glamis" "Thane of Cawdor" and "King hereafter". Following after, the witches don't meet Macbeth again until (Act 4) and during this meeting Macbeth learns three more prophecies that foreshadow his life to come. The three prophecies are an armed head, a bloody child, and a child crowned with a tree in his hand. The importance of the opening scenes and further along in the play start to bring truth of the prophecies in Act 4. In the beginn ing (Act 1, scene 1) of Macbeth the appearance of three witches shed light to what might happen. Everything starts to unravel when the three witches declare to meet up again with each other "when the battle's lost and won". Also a short time after that they yell out together "fair is foul, and foul is fair" this foreshadows that some sort of evil will be coming and that there will also be a victory of sorts to either the witches or the main character in the story, but the audience doesn't know specifically what is to happen. These also suggest a great battle will be fought against good and evil. However these events that are soon to follow will unfold at a rapid pace. This foreshadowing can be detected by the audience because they can feel the suspense... ...liam Shakespeare: Macbeth, the three witches are used as prophets that convey Macbeth's future fate directly to him. Macbeth detects these prophecies not as absolute truths but as predictions that might come true depending on if he thinks they are good or not. For instance at the beginning when the witches declare that they will meet again with each other "When the battle's lost and won". Also when the three witches meet Macbeth and Banquo, they greet Macbeth as three titles. Finally, when The three witches appear to him again they provide three more prophecies that ring actual truth to what is going to happen. The use of these characters in foreshadowing adds to the "tragedy" of the tragedy. Macbeth was foreshadowed or prophesied to commit these acts and die and he knew some and still failed to see them. This adds to the brilliance of Shakespeare's tragedy, Macbeth.

Marketing strategies of the crescent

In the recent years, Amtrak has been forced to undertake new marketing strategies due to declining sales.   As faster and more cost effective ways of traveling have become more popular and cost effective, train travel has had some difficulty keeping up.   However, traveling by train offers some unique opportunities and experiences that are not available with other modes of transportation.   Amtrak is attempting to use these unique attributes to market its train that travels from New York City to New Orleans and back, the Crescent. Amtrak has been marketing the Crescent by emphasizing the comfort that it offers as compared to other forms of transportation.   The new marketing strategies of Amtrak compare the seats of the Crescent with the seats on an airplane and show that the seats on the Crescent more spacious as compared to the seats an airplane.   This marketing strategy is also similar to the new â€Å"travel as you wish† campaign for Amtrak Cascades which emphasizes the comfort and luxuries of traveling by train. Another marketing strategy that Amtrak has employed is by improving the quality of the meals that are served since the Crescent is also equipped with a dining car which serves full meals that are cooked fresh aboard the train.   The menu on board the Crescent has a wide variety of choices to select from and the quality of the food is much better than typical airline food.   In line with this marketing plan, Amtrak has also kept the prices of foods and beverages in its dining car and snack bar reasonable to provide the passenger with all the eating opportunities possible. The marketing strategies for the Crescent that have been utilized by Amtrak also emphasize the fact that train travel is more convenient and enjoyable than any other mode of land transportation, especially for families.   Unlike traveling by car or any other mode of land transportation, traveling by train allows passengers to sit back and enjoy the ride. There is no more need to worry about taking a wrong turn or trying to navigate by using folded maps that are inaccurate or outdated or even finding a nice place to use the restroom.   Amtrak capitalizes on this advantage by marketing its services to families with children by offering discounted rates for children traveling with adults.   This makes train travel a great experience for the entire family because it also allows the children to wander around on board the train as opposed to being confined to the backseat of a car. Boarding a train has also been made much easier by Amtrak to the extent that is has made this even easier than boarding an airplane.   The passengers can avoid long lines and are allowed to keep most of their luggage within easy access of their seat.   This is even better than airplanes which only allow hand carried items of limited dimensions to be stored on board with the passenger and cause a certain level of inconvenience for the passenger, not only during boarding but also upon arrival and waiting at the luggage claim area. Another inconvenience caused by traveling by airplane which Amtrak has used to its advantage it by allowing the use of cellular phones throughout the duration of the train ride.   This advantage appeals to those who have important business to conduct but still prefer to travel comfortably.   The cellular phone use allows businessmen and bankers to be on top of their work while enjoying the many fine facilities and comforts that the Crescent can provide. The Crescent is sometimes equipped with an observation car that allows travelers to climb up to a second level and enjoy a panoramic perspective of their surroundings through its large windows, which unlike in an airplane, allows the train travelers to enjoy much of the scenery as they travel.   This is another advantage that the Crescent has over the modes of transportation because it allows the passenger to literally see life as it passes buy and to experience and behold first hand the breathtaking beauty of America. While there are those who criticize train travel by saying that there are to many stops along the way, the train can still sometimes be a faster option than traveling by car because of the fact that passengers can sleep on a real bed while they travel throughout the night or even during the day thus eliminating the rest stops that accompany traveling by car. The Crescent also offers such comfortable beds that even the passengers sleeping in the coach section of the train have a much more restful and revitalizing rest experience as compared to attempting to sleep in the cramp and uncomfortable seats on an airplane.   Not only does the Crescent allow passengers to be well rested for their arrival at their destination it also makes the travel time much shorter as opposed to traveling by car or by bus. Another convenient aspect of the Crescent, which Amtrak has capitalized on in its marketing strategies, is the fact that most train stations are located right in the middle of downtown business districts.   This is the reason why Amtrak has been marketing train travel as a viable alternative aggressively to business travelers.   Instead of having to go through the hassle of claiming baggage in an airport, finding a taxi, and then finally arriving at your destination, business travelers can walk or take a short subway ride to train station or from the train station to their intended destination. This saves a great deal of time and also allows these weary businessmen to maximize their work days while ensuring that they are not too stressed out or harassed as they normally would through other modes of transportation.   The fact that the Crescent also has comfortable beds and even allow the use of cellular phones provides the businessman with more opportunities to work yet at the same time not feel too harassed or troubled by the time that he arrives at this final destination. Trains are also a good option for business travelers because they are less susceptible to weather delays thus offer greater reliability.   These advantages of trains are the key points in the marketing strategies of Amtrak with respect to its Crescent Line and are the main draws for businessmen. The 9/11 attacks have also increased the volume of passengers on the Crescent Line of Amtrak as more and more Americans realize just how dependent the nation has become on a single mode of transportation which has proven vulnerable to attacks and tragedies.   The tragedy has shown that passenger rail is vital and Amtrak greatly anticipates that more and more Americans will take to traveling by train instead of by airplanes because of this incident.   The spotless record of train travel with regard to hijacking has been a great influence on many American’s decisions to travel by train instead and Amtrak has capitalized on this by giving worried travelers the security option of traveling by train. In August 2005, Hurricane Katrina may have greatly disrupted the Crescent’s route from New York to New Orleans but it also created a unique marketing opportunity for Amtrak. Amtrak used this to its advantage and worked diligently to restore train service to the New Orleans area via the Crescent within a month and a half of the aftermath caused by the hurricane and by doing so became one of the first companies to do so. Many of the railroad tracks leading to the city were severely damaged in the storm.   A press released announced the restoration of train service to the city and Amtrak officials stated that they hoped that having the city accessible by train once again would aid the city in its effort to start rebuilding.   The situation allowed Amtrak to show the people of New Orleans that Amtrak values their city and looks forward to things returning to a more normal pace in the area. Another key step in this was in November 2005, when Amtrak began offering discounted rates to passengers traveling to New Orleans.   Travelers received a twenty percent discount on fares to New Orleans.   Amtrak said they hoped that by making it more affordable, more tourists would be able to travel to New Orleans, boosting not only their sales, but the economy of the city.   The discount was also offered to assist aid workers who traveled to the city. Amtrak has also vied for the business of people traveling on cruises out of New Orleans.   Carnival and Amtrak partnered to offer twenty five percent discounts to passengers traveling on the Crescent to reach the port of New Orleans to depart on their cruise.   The two companies hope that this is an incentive for tourists to travel to New Orleans thus helping the city recover faster.   Amtrak was able to capitalize on this situation by showing that they are more than just a company that cares for the welfare of its passengers but also a company that cares for the welfare of America. These key advantages of traveling by train are also the key marketing strategies of Amtrak in increasing the volume of passengers on its Crescent Line.   The relative comfort, reliability, luxury, convenience and security which the Crescent provides is incentive enough for any businessmen or any traveler for that matter to prefer traveling by train over the modes of transportation throughout America.